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Mr. Meddler

Joined: 13 Jul 2006 Posts: 2208 Location: On the sunny side of the street
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Posted: Wed Dec 02, 2009 12:24 pm Post subject: In The World of Science... |
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uhm...What number is this one? I lost count...
~~~
http://www.nature.com/news/2009/091129/full/news.2009.1114.html
'Temple of the mind' unlocked
Map of fundamental brain receptor opens doors to treatments.
Daniel Cressey
The full structure of a fiendishly complicated and important brain protein has been determined by researchers, potentially enabling the development of new treatments for a wealth of neurological disorders.
Eric Gouaux and his colleagues undertook the difficult task of mapping the structure of a glutamate receptor, a protein that mediates signalling between neurons in the brain and elsewhere in the nervous system. The receptor is also thought to be crucial to processes such as memory and learning.
The resulting picture "tells us things about the organization of the receptor that were just completely unanticipated" says Gouaux, a protein crystallographer at Oregon Health and Science University in Portland. The work appears online today in Nature[1].
The researchers studied a rat glutamate receptor known as GluA2. They grew a crystal of many such proteins, then exposed this to a beam of X-rays. By watching how X-rays scattered from the crystal, they were able to produce an atomic-level picture of a single protein.
In humans, these receptors work as relays for the central nervous system. When the neurotransmitter glutamate binds to the receptor, this opens an 'ion channel' in the neuronal membrane, allowing ions to flow across the membrane. This results in the transmission of an electrical pulse down the nerve.
Inside the temple
Until now, the structure of an intact glutamate receptor has never been seen. Knowing its shape will not only allow scientists to better understand how it works, but should also help those working to develop therapies for conditions in which something goes awry with the system, such as epilepsy and Alzheimer's disease.
The shape of this receptor can now be taken into account when designing molecules that could function as drugs by binding to it. "If you know what the lock looks like then you can better design a key," says Gouaux. "If you don't know you're at a loss."
The GluA2 receptor is shaped like a capital letter Y, and has three main parts. At the top are two prongs, which can enable modification of the receptor. Below this is the area where glutamate binds, triggering the opening of the ion channel. And at the bottom is the channel itself, shaped, say the authors, "like a Mayan temple".
The receptor comprises four subunits, which are chemically identical but, surprisingly, are folded differently (see picture). "The completely astonishing thing was that two subunits are completely different from the other two," says Gouaux. "That difference was totally unanticipated."
Stephen Traynelis, head of a lab that specializes in glutamate receptors at Emory University in Atlanta, Georgia, says that the structure will be a huge boon to research into receptor biology. Previous work involved making inferences — now researchers have a complete receptor mapped they can go back and reinterpret their previous research in light of this.
"This will be enormously useful," Traynelis says. "It's hard to overstate its importance. It's probably one of the most important papers that have come out in this field in the last 10 years."
Gouaux's paper presents the structure with the channel closed. Traynelis says a key future goal is to analyse the structure of the receptor when the ion channel is open.
Crystallizing any membrane protein to allow its structure to be determined with X-rays is a major challenge, says Elek Molnar, a neuroscientist who works on glutamate receptors at the University of Bristol, UK. In the case of this "excellent paper", the researchers chemically locked the receptor into one conformation, with the ion channel closed, to assist in crystallization and visualization.
Future work should allow researchers to see how the receptor interacts with other elements of the nervous system, such as auxiliary proteins. "It is kind of like providing a skeleton," says Molnar. "Now future research can attach muscles, tendons and so on."
References
1. Sobolevsky, A. I., Rosconi, M. P. & Gouaux, E. Nature doi:10.1038/nature08624 (2009). _________________ WARNING: Microwave musclebear detection devices in use on these premises!
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E-boy

Joined: 10 Jul 2006 Posts: 1552 Location: Virginia (Much barfiness)
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Posted: Wed Dec 02, 2009 12:54 pm Post subject: |
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Bah who cares what number we're on. Roman numerals are a pain in the ass anyway, that's why they are quaint little foot notes to the way we do business today. Good article thanks for posting it. _________________ "Life is tough, but it's tougher when you're stupid" ~ SGT John Stryker from "Sands of Iwo Jima". |
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nathan

Joined: 10 Jul 2006 Posts: 6316
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WheelsOfConfusion

Joined: 09 Jul 2006 Posts: 14322 Location: Unknown Kaddath
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Posted: Fri Dec 11, 2009 8:02 pm Post subject: |
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By Jove! |
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The Highlord
Joined: 09 Jul 2006 Posts: 551
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E-boy

Joined: 10 Jul 2006 Posts: 1552 Location: Virginia (Much barfiness)
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Posted: Sat Dec 12, 2009 7:15 pm Post subject: |
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It's a work in progress. Biology is messy messy messy. Which is what makes it so damn entertaining.  _________________ "Life is tough, but it's tougher when you're stupid" ~ SGT John Stryker from "Sands of Iwo Jima". |
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WheelsOfConfusion

Joined: 09 Jul 2006 Posts: 14322 Location: Unknown Kaddath
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tinkeringIdiot

Joined: 13 Oct 2008 Posts: 1057
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Posted: Tue Dec 15, 2009 9:42 am Post subject: |
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Nah...they're mostly harmless. |
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DeD CHiKn

Joined: 03 Aug 2006 Posts: 10229 Location: Baltimore, Maryla*gunshot*
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Posted: Tue Dec 15, 2009 9:46 am Post subject: |
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only a few years away from the elephant sized squid that weave webs on land to catch human prey. |
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ShadowCell
Joined: 02 Aug 2008 Posts: 7395 Location: California
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Posted: Tue Dec 15, 2009 10:03 am Post subject: |
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They'll have to beat the robots and zombies first. |
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DeD CHiKn

Joined: 03 Aug 2006 Posts: 10229 Location: Baltimore, Maryla*gunshot*
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Posted: Tue Dec 15, 2009 10:31 am Post subject: |
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Zombie cephelapods vs robot cephalapods |
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The Highlord
Joined: 09 Jul 2006 Posts: 551
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Posted: Tue Dec 15, 2009 1:02 pm Post subject: |
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If Mass Effect has anything to say about it, the robot cephalopods are going to be our future overlords. _________________ There is a luxury to self-reproach. |
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bad*lil*kitty

Joined: 09 Jul 2006 Posts: 651 Location: body's in IL, heart's in NM
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Posted: Tue Dec 15, 2009 8:02 pm Post subject: |
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fast zombies or slow zombies?
:p _________________ *ahem* |
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Mr Gary
Joined: 29 Apr 2009 Posts: 6888 Location: Some pub in England ... Uh, I mean, Scotland ... Uh, I mean, Spain ... Uh I mean Scotland again ...
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Posted: Tue Dec 15, 2009 8:13 pm Post subject: |
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Dead Space zombies.
Seriously, who could play that game? It made me ingest my own balls.
And wb BLK! |
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bad*lil*kitty

Joined: 09 Jul 2006 Posts: 651 Location: body's in IL, heart's in NM
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Posted: Tue Dec 15, 2009 8:18 pm Post subject: |
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Mr Gary wrote: | Dead Space zombies.
Seriously, who could play that game? It made me ingest my own balls.
And wb BLK! |
Why thankee. _________________ *ahem* |
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